[HTML][HTML] Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin: the role of winged helix …
RK Hall, T Yamasaki, T Kucera, M Waltner-Law… - Journal of Biological …, 2000 - ASBMB
Winged helix/forkhead (Fox) transcription factors have been implicated in the regulation of a
number of insulin-responsive genes. The insulin response elements (IREs) of the
phosphoenolpyruvate carboxykinase (PEPCK) and insulin-like growth factor-binding protein-
1 (IGFBP-1) genes bind members of the FKHR and HNF3 subclasses of Fox proteins.
Previous mutational analyses of the PEPCK and IGFBP-1 IREs revealed mutations which do
not affect the binding of HNF3 proteins to these elements but do eliminate the ability of the …
number of insulin-responsive genes. The insulin response elements (IREs) of the
phosphoenolpyruvate carboxykinase (PEPCK) and insulin-like growth factor-binding protein-
1 (IGFBP-1) genes bind members of the FKHR and HNF3 subclasses of Fox proteins.
Previous mutational analyses of the PEPCK and IGFBP-1 IREs revealed mutations which do
not affect the binding of HNF3 proteins to these elements but do eliminate the ability of the …
