Regulatory role of cytokines in disseminated intravascular coagulation
T van der Poll, E de Jonge… - Seminars in thrombosis …, 2001 - thieme-connect.com
T van der Poll, E de Jonge, M Levi
Seminars in thrombosis and hemostasis, 2001•thieme-connect.comDisseminated intravascular coagulation (DIC) can complicate a number of diseases. DIC in
the setting of sepsis is considered to result from strong activation of the coagulation system
and concurrent inhibition of fibrinolysis and other anticoagulant pathways. Cytokines have
been implicated as important mediators in these hemostatic alterations. This article
summarizes recent insights into which cytokines are likely to be involved in the procoagulant
response to systemic infection.
the setting of sepsis is considered to result from strong activation of the coagulation system
and concurrent inhibition of fibrinolysis and other anticoagulant pathways. Cytokines have
been implicated as important mediators in these hemostatic alterations. This article
summarizes recent insights into which cytokines are likely to be involved in the procoagulant
response to systemic infection.
Abstract
Disseminated intravascular coagulation (DIC) can complicate a number of diseases. DIC in the setting of sepsis is considered to result from strong activation of the coagulation system and concurrent inhibition of fibrinolysis and other anticoagulant pathways. Cytokines have been implicated as important mediators in these hemostatic alterations. This article summarizes recent insights into which cytokines are likely to be involved in the procoagulant response to systemic infection.
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