[HTML][HTML] Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen
GA Di Lullo, SM Sweeney, J Korkko… - Journal of Biological …, 2002 - ASBMB
Type I collagen is the most abundant protein in humans, and it helps to maintain the integrity
of many tissues via its interactions with cell surfaces, other extracellular matrix molecules,
and growth and differentiation factors. Nearly 50 molecules have been found to interact with
type I collagen, and for about half of them, binding sites on this collagen have been
elucidated. In addition, over 300 mutations in type I collagen associated with human
connective tissue disorders have been described. However, the spatial relationships …
of many tissues via its interactions with cell surfaces, other extracellular matrix molecules,
and growth and differentiation factors. Nearly 50 molecules have been found to interact with
type I collagen, and for about half of them, binding sites on this collagen have been
elucidated. In addition, over 300 mutations in type I collagen associated with human
connective tissue disorders have been described. However, the spatial relationships …
