[HTML][HTML] Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation
H Li, A Samouilov, X Liu, JL Zweier - Journal of Biological Chemistry, 2004 - ASBMB
Under anaerobic conditions, xanthine oxidase (XO)-catalyzed nitrite reduction can be an
important source of nitric oxide (NO). However, questions remain regarding whether
significant XO-mediated NO generation also occurs under aerobic conditions. Therefore,
electron paramagnetic resonance, chemiluminescence NO-analyzer, and NO-electrode
studies were performed to characterize the kinetics and magnitude of XO-mediated nitrite
reduction as a function of oxygen tension. With substrates xanthine or 2, 3-dihydroxybenz …
important source of nitric oxide (NO). However, questions remain regarding whether
significant XO-mediated NO generation also occurs under aerobic conditions. Therefore,
electron paramagnetic resonance, chemiluminescence NO-analyzer, and NO-electrode
studies were performed to characterize the kinetics and magnitude of XO-mediated nitrite
reduction as a function of oxygen tension. With substrates xanthine or 2, 3-dihydroxybenz …