Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity
SA Schreyer, TC Lystig, CM Vick, RC LeBoeuf - Atherosclerosis, 2003 - Elsevier
The aims of this study were to determine whether mice induced to become obese also
exhibited accelerated atherosclerosis, and to determine whether obesity itself or
dyslipidemia associated with obesity enhanced atherosclerosis. Wild-type (C57BL/6) mice
and mice deficient for the low density lipoprotein receptor (LDLR−/−) or apolipoprotein E
(apoE−/−) were fed a low fat, rodent chow diet or a high fat, high sucrose (diabetogenic) diet
to induce obesity. As compared with wild-type mice, diabetogenic diet-fed LDLR−/− mice …
exhibited accelerated atherosclerosis, and to determine whether obesity itself or
dyslipidemia associated with obesity enhanced atherosclerosis. Wild-type (C57BL/6) mice
and mice deficient for the low density lipoprotein receptor (LDLR−/−) or apolipoprotein E
(apoE−/−) were fed a low fat, rodent chow diet or a high fat, high sucrose (diabetogenic) diet
to induce obesity. As compared with wild-type mice, diabetogenic diet-fed LDLR−/− mice …
