Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue.
LJ Miller, SH Kurtzman, Y Wang, KH Anderson… - Anticancer …, 1998 - europepmc.org
LJ Miller, SH Kurtzman, Y Wang, KH Anderson, RR Lindquist, DL Kreutzer
Anticancer research, 1998•europepmc.orgMaterials and methods Immunohistochemical analysis for IL-8 receptors (IL-8RA and IL-
8RB) was performed on 43 malignant and 8 benign breast tissue samples. Results Tumor
cells expressed IL-8RA and IL-8RB in all of the malignant specimens. Only 50% of the
benign ductal epithelial cell (DEC) samples expressed these receptors. The majority of small
vessel endothelial cells (SVEC) expressed IL-8RA and IL-8RB, while large vessel
endothelial cells (LVEC) showed primarily IL-8RB expression. Conclusions Our results …
8RB) was performed on 43 malignant and 8 benign breast tissue samples. Results Tumor
cells expressed IL-8RA and IL-8RB in all of the malignant specimens. Only 50% of the
benign ductal epithelial cell (DEC) samples expressed these receptors. The majority of small
vessel endothelial cells (SVEC) expressed IL-8RA and IL-8RB, while large vessel
endothelial cells (LVEC) showed primarily IL-8RB expression. Conclusions Our results …
Materials and methods
Immunohistochemical analysis for IL-8 receptors (IL-8RA and IL-8RB) was performed on 43 malignant and 8 benign breast tissue samples.
Results
Tumor cells expressed IL-8RA and IL-8RB in all of the malignant specimens. Only 50% of the benign ductal epithelial cell (DEC) samples expressed these receptors. The majority of small vessel endothelial cells (SVEC) expressed IL-8RA and IL-8RB, while large vessel endothelial cells (LVEC) showed primarily IL-8RB expression.
Conclusions
Our results demonstrate that tumor and VEC express the IL-8 receptors and likely play a role in regulating tumor and VEC activation which controls proliferation, angiogenesis and metastasis in HBC.
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