Increased replication of HTLV‐I in HTLV‐I–associated myelopathy
M Yoshida, M Osame, H Kawai, M Toita… - Annals of Neurology …, 1989 - Wiley Online Library
M Yoshida, M Osame, H Kawai, M Toita, N Kuwasaki, Y Nishida, Y Hiraki, K Takahashi…
Annals of Neurology: Official Journal of the American Neurological …, 1989•Wiley Online LibraryTo estimate the replication of the human T‐cell leukemia virus type I (HTLV‐I) in patients
with HTLV‐I‐associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV‐I
DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization.
HTLV‐I DNA was detected in 125 (82%) of 153 patients and most showed random
integration. This incidence was much higher than the 29% found in asymtopmatic carriers.
Therefore, HAM/TSP development is associated with a high level of HTLV‐I replication. In …
with HTLV‐I‐associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV‐I
DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization.
HTLV‐I DNA was detected in 125 (82%) of 153 patients and most showed random
integration. This incidence was much higher than the 29% found in asymtopmatic carriers.
Therefore, HAM/TSP development is associated with a high level of HTLV‐I replication. In …
Abstract
To estimate the replication of the human T‐cell leukemia virus type I (HTLV‐I) in patients with HTLV‐I‐associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV‐I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV‐I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymtopmatic carriers. Therefore, HAM/TSP development is associated with a high level of HTLV‐I replication. In addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV‐I DNA, indicating adult T‐cell leukemia.
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