NF-κB and the innate immune response
EN Hatada, D Krappmann, C Scheidereit - Current opinion in immunology, 2000 - Elsevier
EN Hatada, D Krappmann, C Scheidereit
Current opinion in immunology, 2000•ElsevierIn the innate immune reaction, microbial pathogens activate phylogenetically conserved
cellular signal transduction pathways that regulate the ubiquitous nuclear factor-κB (NFκB).
NF-κB has pleiotropic functions in immunity; however, it is also critical for development and
cellular survival. Many aspects of how the different pathways utilize a common kinase
complex that ultimately activates NF-κB have been clarified by gene inactivation and
biochemical analysis.
cellular signal transduction pathways that regulate the ubiquitous nuclear factor-κB (NFκB).
NF-κB has pleiotropic functions in immunity; however, it is also critical for development and
cellular survival. Many aspects of how the different pathways utilize a common kinase
complex that ultimately activates NF-κB have been clarified by gene inactivation and
biochemical analysis.
In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-κB (NFκB). NF-κB has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-κB have been clarified by gene inactivation and biochemical analysis.
Elsevier