[HTML][HTML] Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-κB and pp38 mitogen-activated protein kinase
Expression of mutant proteins or viral infection may interfere with proper protein folding
activity in the endoplasmic reticulum (ER). Several pathways that maintain cellular
homeostasis were activated in response to these ER disturbances. Here we investigated
which of these ER stress-activated pathways induce COX-2 and potentially oncogenesis.
Tunicamycin and brefeldin A, two ER stress inducers, increased the expression of COX-2 in
ML-1 or MCF-7 cells. Nuclear translocation of NF-κB and activation of pp38 MAPK were …
activity in the endoplasmic reticulum (ER). Several pathways that maintain cellular
homeostasis were activated in response to these ER disturbances. Here we investigated
which of these ER stress-activated pathways induce COX-2 and potentially oncogenesis.
Tunicamycin and brefeldin A, two ER stress inducers, increased the expression of COX-2 in
ML-1 or MCF-7 cells. Nuclear translocation of NF-κB and activation of pp38 MAPK were …
