[HTML][HTML] Control of Mycobacterium bovis BCG infection with increased inflammation in TLR4-deficient mice
CMC Fremond, DMM Nicolle, DS Torres… - Microbes and …, 2003 - Elsevier
Live mycobacteria have been reported to signal through several pattern recognition
receptors (PRR), among them toll-like receptor 4 (TLR4) and TLR2 in vitro. Here, we
investigated the role of TLR4 in host resistance to Mycobacterium bovis (BCG) infection in
vivo. In vitro, macrophages of TLR4 mutant C3H/HeJ mice infected with BCG expressed
lower levels of TNF than controls, and TNF release was further decreased, although not
completely absent, in the absence of TLR2. In vivo, TLR4 mutant C3H/HeJ and control …
receptors (PRR), among them toll-like receptor 4 (TLR4) and TLR2 in vitro. Here, we
investigated the role of TLR4 in host resistance to Mycobacterium bovis (BCG) infection in
vivo. In vitro, macrophages of TLR4 mutant C3H/HeJ mice infected with BCG expressed
lower levels of TNF than controls, and TNF release was further decreased, although not
completely absent, in the absence of TLR2. In vivo, TLR4 mutant C3H/HeJ and control …
