Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions
S Lev, H Moreno, R Martinez, P Canoll, E Peles… - Nature, 1995 - nature.com
Nature, 1995•nature.com
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system,
is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the
intracellular calcium concentration, as well as by protein kinase C activation. Activation of
PYK2 leads to modulation of ion channel function and activation of the MAP kinase
signalling pathway. PYK2 activation may provide a mechanism for a variety of short-and
long-term calcium-dependent signalling events in the nervous system.
is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the
intracellular calcium concentration, as well as by protein kinase C activation. Activation of
PYK2 leads to modulation of ion channel function and activation of the MAP kinase
signalling pathway. PYK2 activation may provide a mechanism for a variety of short-and
long-term calcium-dependent signalling events in the nervous system.
Abstract
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.
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