Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
JJ Campbell, EC Butcher - Current opinion in immunology, 2000 - Elsevier
JJ Campbell, EC Butcher
Current opinion in immunology, 2000•ElsevierThis review describes recent breakthroughs in our understanding of the roles played by
chemokines in lymphocyte trafficking. These include the first demonstration that chemokines
control lymphocyte/vascular recognition by shear-resistant rapid adhesion; the first example
of specialized tissue-specific homing mediated by chemokines; and the implication that
chemokines may control microenvironmental segregation within lymphoid organs.
chemokines in lymphocyte trafficking. These include the first demonstration that chemokines
control lymphocyte/vascular recognition by shear-resistant rapid adhesion; the first example
of specialized tissue-specific homing mediated by chemokines; and the implication that
chemokines may control microenvironmental segregation within lymphoid organs.
This review describes recent breakthroughs in our understanding of the roles played by chemokines in lymphocyte trafficking. These include the first demonstration that chemokines control lymphocyte/vascular recognition by shear-resistant rapid adhesion; the first example of specialized tissue-specific homing mediated by chemokines; and the implication that chemokines may control microenvironmental segregation within lymphoid organs.
Elsevier
