Diabetic neuropathy is not a single entity but rather a number of different syndromes, each with a range of clinical and subclinical manifestations. According to the San Antonio Conference [1], the main groups of neurologic disturbance in diabetes mellitus include subclinical neuropathy determined by abnormalities in electrodiagnostic and quantitative sensory testing, diffuse clinical neuropathy with distal symmetric sensorimotor and autonomic syndromes, and focal syndromes. There is reason to add proximal neuropathy as a separate entity based on the nature of the pathology and response to treatment. However, we have found it more appropriate to classify neuropathy into different clinical syndromes based on their pathogenesis because this is what ultimately determines the choice of treatment. We classify neuropathies into somatic and autonomic. There are two types of somatic neuropathy: focal and diffuse. The focal neuropathies include mononeuritis and entrapment syndromes. The diffuse neuropathies include proximal neuropathies and large- and small-fiber distal symmetric polyneuropathies.