[HTML][HTML] Caspase 3-mediated cleavage of p21 WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 …
YH Jin, KJ Yoo, YH Lee, SK Lee - Journal of Biological Chemistry, 2000 - ASBMB
Apoptosis of SK-HEP-1 human hepatoma cells induced by treatment with ginsenoside Rh2
(G-Rh2) is associated with rapid and selective activation of cyclin A-associated cyclin-
dependent kinase 2 (Cdk2). Here, we show that in apoptotic cells, the Cdk inhibitory protein
p21 WAF1/CIP1, which is associated with the cyclin A-Cdk2 complex, undergoes selective
proteolytic cleavage. In contrast, another Cdk inhibitory protein, p27 KIP1, which is
associated with cyclin A-Cdk2 and cyclin E-Cdk2 complexes, remained unaltered during …
(G-Rh2) is associated with rapid and selective activation of cyclin A-associated cyclin-
dependent kinase 2 (Cdk2). Here, we show that in apoptotic cells, the Cdk inhibitory protein
p21 WAF1/CIP1, which is associated with the cyclin A-Cdk2 complex, undergoes selective
proteolytic cleavage. In contrast, another Cdk inhibitory protein, p27 KIP1, which is
associated with cyclin A-Cdk2 and cyclin E-Cdk2 complexes, remained unaltered during …
