[HTML][HTML] Regulation of the calmodulin-stimulated protein phosphatase, calcineurin
CB Klee, H Ren, X Wang - Journal of Biological Chemistry, 1998 - ASBMB
The role of protein phosphatases in the regulation of cellular processes is now well
established (1, 2). Calcineurin (also called protein phosphatase 2B), a major calmodulin-
binding protein in brain and the only serine/threonine protein phosphatase under the control
of Ca2+/calmodulin, plays a critical role in the coupling of Ca2+ signals to cellular responses
(3–6). Its stimulation by the multifunctional protein, calmodulin, ensures the coordinated
regulation of its protein phosphatase activity with the activities of the many other enzymes …
established (1, 2). Calcineurin (also called protein phosphatase 2B), a major calmodulin-
binding protein in brain and the only serine/threonine protein phosphatase under the control
of Ca2+/calmodulin, plays a critical role in the coupling of Ca2+ signals to cellular responses
(3–6). Its stimulation by the multifunctional protein, calmodulin, ensures the coordinated
regulation of its protein phosphatase activity with the activities of the many other enzymes …
