Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD
L Claesson-Welsh, M Welsh, N Ito… - Proceedings of the …, 1998 - National Acad Sciences
Proceedings of the National Academy of Sciences, 1998•National Acad Sciences
Angiostatin, a fragment of plasminogen, has been identified and characterized as an
endogenous inhibitor of neovascularization. We show that angiostatin treatment of
endothelial cells in the absence of growth factors results in an increased apoptotic index
whereas the proliferation index is unchanged. Angiostatin also inhibits migration and tube
formation of endothelial cells. Angiostatin treatment has no effect on growth factor-induced
signal transduction but leads to an RGD-independent induction of the kinase activity of focal …
endogenous inhibitor of neovascularization. We show that angiostatin treatment of
endothelial cells in the absence of growth factors results in an increased apoptotic index
whereas the proliferation index is unchanged. Angiostatin also inhibits migration and tube
formation of endothelial cells. Angiostatin treatment has no effect on growth factor-induced
signal transduction but leads to an RGD-independent induction of the kinase activity of focal …
Angiostatin, a fragment of plasminogen, has been identified and characterized as an endogenous inhibitor of neovascularization. We show that angiostatin treatment of endothelial cells in the absence of growth factors results in an increased apoptotic index whereas the proliferation index is unchanged. Angiostatin also inhibits migration and tube formation of endothelial cells. Angiostatin treatment has no effect on growth factor-induced signal transduction but leads to an RGD-independent induction of the kinase activity of focal adhesion kinase, suggesting that the biological effects of angiostatin relate to subversion of adhesion plaque formation in endothelial cells.
National Acad Sciences
