Cancer development requires the accumulation of numerous genetic changes which are
usually believed to occur through the presence of unrepaired DNA lesions. Exogenous or
endogenous DNA-damaging agents can lead to mutations in the absence of efficient error-
free repair, via replication of DNA damage. Several DNA repair pathways are present in
living cells and well-conserved from bacteria to human cells. The nucleotide excision repair
(NER), the most versatile of these DNA repair systems, recognizes and eliminates a wide …