DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
D Durocher, SP Jackson - Current opinion in cell biology, 2001 - Elsevier
Current opinion in cell biology, 2001•Elsevier
The DNA damage signalling pathway is a core element of the cellular response to genotoxic
insult, and its components play key roles in defending against neoplastic transformation.
Recent work has indicated that the human ATM and ATR proteins, and their yeast
homologues, are intimately involved in sensing DNA damage, suggesting parallels with the
DNA double-strand break repair enzyme DNA-PK.
insult, and its components play key roles in defending against neoplastic transformation.
Recent work has indicated that the human ATM and ATR proteins, and their yeast
homologues, are intimately involved in sensing DNA damage, suggesting parallels with the
DNA double-strand break repair enzyme DNA-PK.
The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.
Elsevier
