Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence

RVN Lord, D Salonga, KD Danenberg… - Journal of …, 2000 - Elsevier
Barrett's esophagus is a multistage polyclonal disease that is associated with the
development of adenocarcinoma of the esophagus and esophagogastric junction.
Telomerase activation is associated with cellular immortality and carcinogenesis, and
increased expression of the telomerase reverse transcriptase catalytic subunit (hTERT) has
been used for the early detection of malignant diseases. To identify biomarkers associated
with each stage of the Barrett's process, relative mRNA expression levels of hTERT were …