Reduced telomere length in ataxia-telangiectasia fibroblasts
SJ Xia, MA Shammas, RJS Reis - Mutation Research/DNA Repair, 1996 - Elsevier
Chromosomal instability with a high frequency of telomere fusion is characteristic of ataxia-
telangiectasia cells both in vivo and in vitro. We have measured telomere length and found it
to be consistently reduced in both diploid and SV40-transformed cells AT fibroblasts, relative
to control cells. We examined a few possible mechanisms which might account for telomeric
length reduction, including telomerase activity in transformed cells and endogenous
nuclease activities, but found no differences between AT and control cells in these …
telangiectasia cells both in vivo and in vitro. We have measured telomere length and found it
to be consistently reduced in both diploid and SV40-transformed cells AT fibroblasts, relative
to control cells. We examined a few possible mechanisms which might account for telomeric
length reduction, including telomerase activity in transformed cells and endogenous
nuclease activities, but found no differences between AT and control cells in these …