Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
ContextSeptic shock may be associated with relative adrenal insufficiency. Thus, a
replacement therapy of low doses of corticosteroids has been proposed to treat septic shock.
ObjectiveTo assess whether low doses of corticosteroids improve 28-day survival in patients
with septic shock and relative adrenal insufficiency. Design and SettingPlacebo-controlled,
randomized, double-blind, parallel-group trial performed in 19 intensive care units in France
from October 9, 1995, to February 23, 1999. PatientsThree hundred adult patients who …
replacement therapy of low doses of corticosteroids has been proposed to treat septic shock.
ObjectiveTo assess whether low doses of corticosteroids improve 28-day survival in patients
with septic shock and relative adrenal insufficiency. Design and SettingPlacebo-controlled,
randomized, double-blind, parallel-group trial performed in 19 intensive care units in France
from October 9, 1995, to February 23, 1999. PatientsThree hundred adult patients who …