Evidence of enhanced recombinant interleukin-2 sensitivity in thymic lymphocytes from patients with myasthenia gravis: possible role in autoimmune pathogenesis
S Cohen-Kaminsky, P Levasseur, JP Binet… - Journal of …, 1989 - Elsevier
We evaluated the activation state of thymic lymphocytes in patients with myasthenia gravis
(MG) by cytofluorographic analysis of CD25 expression and by testing their sensitivity to
recombinant interkeukin-2 (rIL-2) in the absence of any known previous stimulation. We
detected no phenotypic signs of activation in fresh MG thymic lymphocyte suspensions,
while functional signs of activation were reflected in a significantly higher sensitivity to rIL-2
in MG patients than in controls. The responses to rIL-2 were time-and dose-dependent, were …
(MG) by cytofluorographic analysis of CD25 expression and by testing their sensitivity to
recombinant interkeukin-2 (rIL-2) in the absence of any known previous stimulation. We
detected no phenotypic signs of activation in fresh MG thymic lymphocyte suspensions,
while functional signs of activation were reflected in a significantly higher sensitivity to rIL-2
in MG patients than in controls. The responses to rIL-2 were time-and dose-dependent, were …