Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice
RS Abraham, CS David - Current opinion in immunology, 2000 - Elsevier
RS Abraham, CS David
Current opinion in immunology, 2000•ElsevierThe past year has seen a spate of research in the use of HLA transgenic mice in the
identification of self antigens associated with autoimmunity. Dominant T cell determinants—
and, in a few cases, B cell determinants—have been characterized in the context of disease-
predisposing HLA DR and DQ genes for at least three prominent and devastating
autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent
diabetes mellitus.
identification of self antigens associated with autoimmunity. Dominant T cell determinants—
and, in a few cases, B cell determinants—have been characterized in the context of disease-
predisposing HLA DR and DQ genes for at least three prominent and devastating
autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent
diabetes mellitus.
The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants — and, in a few cases, B cell determinants — have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.
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