Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes
J Duranteau, NS Chandel, A Kulisz, Z Shao… - Journal of biological …, 1998 - ASBMB
Cardiomyocytes suppress contraction and O 2 consumption during hypoxia. Cytochrome
oxidase undergoes a decrease in V max during hypoxia, which could alter mitochondrial
redox and increase generation of reactive oxygen species (ROS). We therefore tested
whether ROS generated by mitochondria act as second messengers in the signaling
pathway linking the detection of O 2 with the functional response. Contracting
cardiomyocytes were superfused under controlled O 2 conditions while fluorescence …
oxidase undergoes a decrease in V max during hypoxia, which could alter mitochondrial
redox and increase generation of reactive oxygen species (ROS). We therefore tested
whether ROS generated by mitochondria act as second messengers in the signaling
pathway linking the detection of O 2 with the functional response. Contracting
cardiomyocytes were superfused under controlled O 2 conditions while fluorescence …
