Effect of the late complement components C5b-9 on human monocytes: release of prostanoids, oxygen radicals and of a factor inducing cell proliferation
GM Hänsch, M Seitz, M Betz - International Archives of Allergy and …, 1987 - karger.com
GM Hänsch, M Seitz, M Betz
International Archives of Allergy and Immunology, 1987•karger.comRecently, we reported stimulation of rat macrophages and human platelets by isolated C5b-
9 to synthesize prostaglandin E (PGE) or thromboxane B2 (TXB2). In the present study, we
tested whether besides prostanoids, C5b-9 also would induce the production of other
mediators. We found that C5b-9 in sublytic concentrations stimulated human granulocytes
(polymorphonuclear leukocytes) or monocytes to release oxygen radicals. Furthermore,
monocytes release interleukin-1 in response to C5b-9. Thus, besides having a lytic capacity …
9 to synthesize prostaglandin E (PGE) or thromboxane B2 (TXB2). In the present study, we
tested whether besides prostanoids, C5b-9 also would induce the production of other
mediators. We found that C5b-9 in sublytic concentrations stimulated human granulocytes
(polymorphonuclear leukocytes) or monocytes to release oxygen radicals. Furthermore,
monocytes release interleukin-1 in response to C5b-9. Thus, besides having a lytic capacity …
Abstract
Recently, we reported stimulation of rat macrophages and human platelets by isolated C5b-9 to synthesize prostaglandin E (PGE) or thromboxane B2 (TXB2). In the present study, we tested whether besides prostanoids, C5b-9 also would induce the production of other mediators. We found that C5b-9 in sublytic concentrations stimulated human granulocytes (polymorphonuclear leukocytes) or monocytes to release oxygen radicals. Furthermore, monocytes release interleukin-1 in response to C5b-9. Thus, besides having a lytic capacity, C5b-9 also functions as a stimulator of various cells.
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