Mechanism of suppression of cell-mediated immunity by measles virus
CL Karp, M Wysocka, LM Wahl, JM Ahearn, PJ Cuomo… - Science, 1996 - science.org
CL Karp, M Wysocka, LM Wahl, JM Ahearn, PJ Cuomo, B Sherry, G Trinchieri, DE Griffin
Science, 1996•science.orgThe mechanisms underlying the profound suppression of cell-mediated immunity (CMI)
accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from
monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV)
infection of primary human monocytes specifically down-regulated IL-12 production. Cross-
linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with
antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 …
accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from
monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV)
infection of primary human monocytes specifically down-regulated IL-12 production. Cross-
linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with
antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 …
The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.
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