Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-α following closed head injury in mice
PF Stahel, K Kariya, E Shohami, SR Barnum… - Journal of …, 2000 - Elsevier
The anaphylatoxin C5a is a potent mediator of inflammation in the CNS. We analyzed the
intracerebral expression of the C5a receptor (C5aR) in a model of closed head injury (CHI)
in mice. Up-regulation of C5aR mRNA and protein expression was observed mainly on
neurons in sham-operated and head-injured wild-type mice at 24 h. In contrast, in
TNF/lymphotoxin-α knockout mice, the intracerebral C5aR expression remained at low
constitutive levels after sham operation, whereas it strongly increased in response to trauma …
intracerebral expression of the C5a receptor (C5aR) in a model of closed head injury (CHI)
in mice. Up-regulation of C5aR mRNA and protein expression was observed mainly on
neurons in sham-operated and head-injured wild-type mice at 24 h. In contrast, in
TNF/lymphotoxin-α knockout mice, the intracerebral C5aR expression remained at low
constitutive levels after sham operation, whereas it strongly increased in response to trauma …
