Renin can be detected in cardiovascular and other tissues but it disappears after bilateral
nephrectomy indicating that tissues can take up or bind renal renin from the circulation. If
renin uptake is the result of specific binding, plasma prorenin may be a natural antagonist of
tissue directed renin-angiotensin systems. To investigate if specific prorenin/renin uptake
occurs in rat tissues, binding studies were performed with rat microsomal membrane
preparations using recombinant rat prorenin metabolically labeled with 35S-methionine as a …