Role of Oncostatin M in hematopoiesis and liver development
A Miyajima, T Kinoshita, M Tanaka, A Kamiya… - Cytokine & growth factor …, 2000 - Elsevier
Definitive hematopoietic stem cells (HSCs) first appear in the aorta/gonad/mesonephros
(AGM) region and migrate to the fetal liver where they massively produce hematopoietic
cells before establishing hematopoiesis in the bone marrow at a perinatal stage. In the AGM
region, Oncostatin M (OSM) enhances the development of both hematopoietic and
endothelial cells by possibly stimulating their common precursors, so-called
hemangioblasts. During development of HSCs in the AGM region, the liver primodium is …
(AGM) region and migrate to the fetal liver where they massively produce hematopoietic
cells before establishing hematopoiesis in the bone marrow at a perinatal stage. In the AGM
region, Oncostatin M (OSM) enhances the development of both hematopoietic and
endothelial cells by possibly stimulating their common precursors, so-called
hemangioblasts. During development of HSCs in the AGM region, the liver primodium is …