[HTML][HTML] Agouti and agouti-related protein: analogies and contrasts
DM Dinulescu, RD Cone - Journal of Biological Chemistry, 2000 - ASBMB
The discovery a decade ago of the murine agouti gene was intended to bring scientists a
step closer to understanding the complexities of mammalian pigmentation. The first obesity
gene was also uncovered in the process. What followed was an explosion of major
discoveries in murine as well as human obesity and diabetes research. Recently, a new
gene, the agouti-related protein (AGRP), 1 was discovered and found to share a striking
similarity in structure and function with agouti, although their patterns of distribution are …
step closer to understanding the complexities of mammalian pigmentation. The first obesity
gene was also uncovered in the process. What followed was an explosion of major
discoveries in murine as well as human obesity and diabetes research. Recently, a new
gene, the agouti-related protein (AGRP), 1 was discovered and found to share a striking
similarity in structure and function with agouti, although their patterns of distribution are …
