Apoptosis of smooth muscle cells is not silent: Fas/FADD initiates a program of inflammatory gene expression
DF Bowen-Pope, FJ Schaub - Trends in Cardiovascular Medicine, 2001 - Elsevier
Unlike necrosis, apoptosis is classically considered to be “silent,”(ie, self-contained and non-
inflammatory). In this review, we describe the system that we developed to regulate
apoptosis of smooth muscle cells (SMC) in vivo. We have used this system to demonstrate
that SMC apoptosis initiated by FADD or by Fas ligation includes a specific program of
expression of pro-inflammatory genes. We discuss how this conclusion can be reconciled
with reports that Fas plays an anti-inflammatory role in vascular lesions.
inflammatory). In this review, we describe the system that we developed to regulate
apoptosis of smooth muscle cells (SMC) in vivo. We have used this system to demonstrate
that SMC apoptosis initiated by FADD or by Fas ligation includes a specific program of
expression of pro-inflammatory genes. We discuss how this conclusion can be reconciled
with reports that Fas plays an anti-inflammatory role in vascular lesions.
