Astrocytes have a critical role in the neuronal response to ischemia, as their production of
neurotrophic mediators can favorably impact on the extreme sensitivity of nervous tissue to
oxygen deprivation. Using a differential display method, a novel putative RNA binding
protein, RA301, was cloned from reoxygenated astrocytes. Analysis of the deduced amino
acid sequence showed two ribonucleoprotein domains and serine/arginine-rich domains,
suggestive of their function as RNA splicing factor. Northern analysis displayed striking …