Monoclonal antibodies raised against human acetylcholine receptor bind to all five subunits of the fetal isoform
The human muscle acetylcholine receptor (AChR) is an oligomeric membrane protein
consisting of (α1) 2, β, δ, ε subunits in the adult form and (α1) 2, β, γ, δ in the fetal form. The
adult AChR is the target for autoantibodies in myasthenia gravis (MG), and antibodies that
block the function of fetal AChR can cross the placenta and paralyse the developing baby
causing joint contractures. Monoclonal antibodies (mAbs) raised against purified AChR
were characterised previously in terms of binding to five regions, three of which appeared to …
consisting of (α1) 2, β, δ, ε subunits in the adult form and (α1) 2, β, γ, δ in the fetal form. The
adult AChR is the target for autoantibodies in myasthenia gravis (MG), and antibodies that
block the function of fetal AChR can cross the placenta and paralyse the developing baby
causing joint contractures. Monoclonal antibodies (mAbs) raised against purified AChR
were characterised previously in terms of binding to five regions, three of which appeared to …
