The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
A Veillette, MA Bookman, EM Horak, JB Bolen - Cell, 1988 - cell.com
A Veillette, MA Bookman, EM Horak, JB Bolen
Cell, 1988•cell.comSummary The CD4 and CD8 T cell antigens are thought to transduce an independent signal
during the process of T cell activation. We report our evaluation of the possible involvement
of the lymphocyte-specific tyrosine kinase~ 56”~ in these transduction pathways. Our data
demonstrate that p56jCk is specifically modulated with either CD4 or CD8 following
antibodymediated cross-linking of these molecules and that a large fraction of the total
cellular Ick protein can be coimmunoprecipitated with these surface glycoproteins. These …
during the process of T cell activation. We report our evaluation of the possible involvement
of the lymphocyte-specific tyrosine kinase~ 56”~ in these transduction pathways. Our data
demonstrate that p56jCk is specifically modulated with either CD4 or CD8 following
antibodymediated cross-linking of these molecules and that a large fraction of the total
cellular Ick protein can be coimmunoprecipitated with these surface glycoproteins. These …
Summary
The CD4 and CD8 T cell antigens are thought to transduce an independent signal during the process of T cell activation. We report our evaluation of the possible involvement of the lymphocyte-specific tyrosine kinase~ 56”~ in these transduction pathways. Our data demonstrate that p56jCk is specifically modulated with either CD4 or CD8 following antibodymediated cross-linking of these molecules and that a large fraction of the total cellular Ick protein can be coimmunoprecipitated with these surface glycoproteins. These results suggest that~ 56’~~ is functionally and physically associated with CD4/CD8 in normal murine T lymphocytes and support the concept that an independent signal is transduced by the interaction of these surface molecules with major histocompatibility complex determinants.
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