The preferential cytotoxicity of reovirus for certain transformed cell lines
G Hashiro, PC Loh, JT Yau - Archives of virology, 1977 - Springer
G Hashiro, PC Loh, JT Yau
Archives of virology, 1977•SpringerThe susceptibility of a variety of cell lines of different mammalian origin to cytotoxic (CT)
induction by either ultraviolet light-irradiated reovirus type 2 (UVR2) or viable reovirus type 2
plus the protein synthesis inhibitor, cycloheximide, was examined. The following groups of
cells were found to be susceptible to CT-induction: certain tumor cells and spontaneously
transformed cell lines of human origin and certain virally and spontaneously transformed cell
lines of murine origin. The following groups of cells were found to be resistant: normal …
induction by either ultraviolet light-irradiated reovirus type 2 (UVR2) or viable reovirus type 2
plus the protein synthesis inhibitor, cycloheximide, was examined. The following groups of
cells were found to be susceptible to CT-induction: certain tumor cells and spontaneously
transformed cell lines of human origin and certain virally and spontaneously transformed cell
lines of murine origin. The following groups of cells were found to be resistant: normal …
Summary
The susceptibility of a variety of cell lines of different mammalian origin to cytotoxic (CT) induction by either ultraviolet light-irradiated reovirus type 2 (UVR2) or viable reovirus type 2 plus the protein synthesis inhibitor, cycloheximide, was examined. The following groups of cells were found to be susceptible to CT-induction: certain tumor cells and spontaneously transformed cell lines of human origin and certain virally and spontaneously transformed cell lines of murine origin. The following groups of cells were found to be resistant: normal human diploid cell lines, primary and continuous cell cultures of subhuman primates, primary mouse cells, normal rat kidney cells and baby hamster kidney cells. Susceptibility to CT-induction could not be related to the adsorption of virus to cells, nor to the capacity of the cell to support virus replication.
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