p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors
V Baron, V Calléja, P Ferrari, F Alengrin… - Journal of Biological …, 1998 - ASBMB
The focal adhesion kinase p125 Fak is a widely expressed cytosolic tyrosine kinase, which
is involved in integrin signaling and in signal transduction of a number of growth factors. In
contrast to tyrosine kinase receptors such as the platelet-derived growth factor and the
hepatocyte growth factor receptors, which induce p125 Fak phosphorylation, insulin has
been shown to promote its dephosphorylation. In this study, we compared p125 Fak
phosphorylation in insulin-stimulated cells maintained in suspension or in an adhesion …
is involved in integrin signaling and in signal transduction of a number of growth factors. In
contrast to tyrosine kinase receptors such as the platelet-derived growth factor and the
hepatocyte growth factor receptors, which induce p125 Fak phosphorylation, insulin has
been shown to promote its dephosphorylation. In this study, we compared p125 Fak
phosphorylation in insulin-stimulated cells maintained in suspension or in an adhesion …
