Biochemistry of the Src protein-tyrosine kinase: regulation by SH2 and SH3 domains
X Liu, T Pawson - Proceedings of the 1992 Laurentian Hormone …, 1994 - Elsevier
pp60 c-Srs (c-Src) is the prototype for a family of cytoplasmic protein-tyrosin kinases
involved in the control of signal transduction. In addition to the enzymatic kinase domain, c-
Src has several noncatalytic domains which regulate Src tyrosine kinase activity in both a
positive and a negative fashion. Phosphorylation of c-Src at Tyr 527 in the noncatalytic C-
terminal tail is a key mechanism for repression of c-Src tyrosine kinase activity. This
inhibitory phosphorylation is apparently catalyzed by another cytoplasmic tyrosine kinase …
involved in the control of signal transduction. In addition to the enzymatic kinase domain, c-
Src has several noncatalytic domains which regulate Src tyrosine kinase activity in both a
positive and a negative fashion. Phosphorylation of c-Src at Tyr 527 in the noncatalytic C-
terminal tail is a key mechanism for repression of c-Src tyrosine kinase activity. This
inhibitory phosphorylation is apparently catalyzed by another cytoplasmic tyrosine kinase …
