[HTML][HTML] Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells (∗)
JK Jackman, DG Motto, Q Sun, M Tanemoto… - Journal of Biological …, 1995 - ASBMB
The activation of protein tyrosine kinases is a critical event in T cell antigen receptor (TCR)-
mediated signaling. One substrate of the TCR-activated protein tyrosine kinase pathway is a
76-kDa protein (pp76) that associates with the adaptor protein Grb2. In this report we
describe the purification of pp76 and the molecular cloning of its cDNA, which encodes a
novel 533-amino acid protein with a single carboxyl-terminal Src homology 2 (SH2) domain.
Although no recognizable motifs related to tyrosine, serine/threonine, or lipid kinase …
mediated signaling. One substrate of the TCR-activated protein tyrosine kinase pathway is a
76-kDa protein (pp76) that associates with the adaptor protein Grb2. In this report we
describe the purification of pp76 and the molecular cloning of its cDNA, which encodes a
novel 533-amino acid protein with a single carboxyl-terminal Src homology 2 (SH2) domain.
Although no recognizable motifs related to tyrosine, serine/threonine, or lipid kinase …
