Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins
Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through
association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that
specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and
modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-
dependent protein kinase to calcium channels and enhances their regulation in multiple cell
types.
association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that
specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and
modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-
dependent protein kinase to calcium channels and enhances their regulation in multiple cell
types.
Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types.
Elsevier
